Researchers at the Indian Institute of Technology, Bathing, found a biochemical relationship between fatty liver disease and type 2 diabetes mellitus (T2DM). This understanding allows newer techniques to diagnose the risk of diabetes among people with non-alcoholic fatty liver disease (NAFLD). This finding also has the potential to offer new therapeutic paths to control or even reverse diabetes that is induced by the liver.
Research findings have been published in the Journal of Diabetes. The paper has been jointly authord by prosjit mondal, associate professor, school of biosciences and bioengineering, research scholars Surbhi Dogra, Priya Rawat, P Vineeth Daniel from IIT bath, partha chakrabarti Sujay K. Maity, Avishek Paul together with Dr. Kausik Das, and Dr. Souveek Mitra from IPGmer and SSKM Hospital, Kolkata. Explain the importance of research, Mondal, said: “Nafld is an independent predictor of insulin resistance and T2DM.
However, how nafld affects the function of the β pancreas cell release insulin is not fully understood. “We aim to find the relationship between the failure of β cells and the accumulation of liver fats produced from carbohydrates in a process called lipogenesis de novo.” He says. The multi-institutional research team analyzes blood samples extracted from mice that are fed fat and human nafld patients. Both samples have a high amount of calcium -fasted protein called S100A6, which is released by fatty hearts and functions as a communication relationship between the liver and pancreas.
S100A6 protein affects the ability of insulin secretion from β cells, resulting in or worsening existing T2DM. At the biochemical level, S100A6 is found to inhibit insulin secretion by activating receptors for the final product of advanced gups (Rage) in pancreatic beta cells, the word back. Describing the critical work, Surbhi Dogra, said that another important observation of our research was that “S100A6 thinning increases insulin secretion and blood glucose regulation in mice.”
This study is important in many ways, he said, added that at the scientific level, he presented molecular and cellular events related to S100A6 secretion in fatty liver, and its adverse effects on the release of β cell insulin. From a practical and diagnostic angle, this shows that an increase in levels of S100A6 in the blood can function as a biomarker to identify the risk of T2DM among nafld patients, said Dogra. Mondal said the research was important for India because the prevalence of Nafld increased rapidly in the country and the new survey showed that 40% of Indian adults suffered from it.